Prevention of Chemotherapy-Induced Neuropathy: Leukemia Inhibitory Factor
نویسندگان
چکیده
منابع مشابه
Prevention of chemotherapy-induced neuropathy: leukemia inhibitory factor.
Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...
متن کاملPrevention of Chemotherapy-Induced Neuropathy: Leukemia Inhibitory Factor
Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...
متن کاملThe Biology Behind Prevention of Chemotherapy-Induced Neuropathy: Leukemia Inhibitory Factor
Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...
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The incidence of chemotherapy-induced peripheral neuropathy (CIPN) in the population of cancer patients is estimated at 3-7% in cytostatic monotherapy and as high as 38% in the case of polytherapy. While testing drugs that may reduce the damage to the peripheral nervous system, particular attention should be paid to their protective action against the severe and painful complication in the pati...
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Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating complication associated with drug treatment of cancer. For which there are no effective strategies of prevention or treatment. In this study we examined the effect of intermittent expression of neurotophin-3 (NT-3) or interleukin 10 (IL-10) from replication-defective herpes simplex virus (HSV)-based regulatable vectors delivere...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2005
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-05-0079